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Growth Factors, June 2009

Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

[137] found that the sesquiterpene CA-4 in the seed extract of Artemisia argyi exerts anti-inflammatory effects through a dual mechanism: 1) Inhibiting the MAPK pathway (phosphorylation of ERK/JNK), down-regulating the expression of iNOS/COX-2, and blocking the polarization of M1 macrophages

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219,220 Additionally, NF-B serves as a central mediator for the activation initiation signal of the NLRP3 inflammasome, responding to various PRR ligands and cytokines by inducing the transcriptional expression of NLRP3 and pro-IL-1